We focus on exploring the intricate interactions between the microbiome, particularly nasal and gut bacteria, and local immune system in tissues. We aim to investigate the connection between these microbiome-immune interactions and their relevance to infectious diseases, inflammatory disorders, cancers, and neurological disorders. By studying the role of nasal and gut bacteria in modulating immune responses, we seek to uncover potential links between the microbiome and various health conditions, paving the way for potential therapeutic strategies.The research investigates how nasal and gut bacteria influence the immune response and contribute to the development and progression of infectious diseases. By examining the mechanisms through which these bacteria interact with the immune system, we aim to understand their impact on infection susceptibility, disease severity, and immune defense. Additionally, the research explores the association between nasal and gut bacteria and inflammatory disorders, such as inflammatory bowel disease, asthma, and autoimmune diseases. Understanding how these bacteria shape immune responses and contribute to inflammation will provide insights into potential interventions targeting the microbiome to manage and treat these disorders effectively.Furthermore, the research examines the potential link between nasal and gut bacteria and the development of cancers and neurological disorders. By studying the influence of the microbiome on immune surveillance, inflammation, and tumor progression, the research aims to uncover how nasal and gut bacteria may contribute to cancer development. Similarly, exploring the gut-brain axis and the impact of nasal and gut bacteria on neuroinflammation and neurotransmitter regulation may shed light on their role in the pathogenesis of neurological disorders. Ultimately, this research topic seeks to unravel the microbiome-immune interactions, particularly involving nasal and gut bacteria, and their implications for infectious diseases, inflammatory disorders, cancers, and neurological disorders, providing a foundation for potential therapeutic advancements.