Publications: first or corresponding author (Since 2019)
Peer-reviewed publications – See also Google Scholar
*# Denotes equal contributions
1. Early-life brain-resident Tregs establish lifelong CNS immune niche and synaptic homeostasis. Leechung Chang, Juli Choi, Meng Li, Zu-qing Nie, Eunkyu Hwang, Yeo-Jin Jeong, Haewon Park, Jong-Hwi Yoon, Gi-Cheon Kim, Lin Zhao, Sungji Ha, Keun-Ah Cheon, Suhyun Yoon, Jongshin Kim, Hyo-Bin Jung, Eunee Lee, Xia Cao*, Ho-Keun Kwon*. Under review
2. Nasal ST2⁺ regulatory T cells restrain Tc1-Neutrophil axis in chronic rhinosinusitisHaewon Park, Hyobin Jung, Yong Ju Jang, Gi-Cheon Kim, Jong-Hwi Yoon, Siyoon Kim, Juli Choi, Myeong Sang Yu, Yoo-Sam Chung, Young Hoon Kim, Ji Heui Kim#, Ho-Keun Kwon#. Under review
3. Pregnancy-expanded regulatory T cells constrain maternal inflammation to protect fetal neurodevelopment. Jinseok Park#, Zalosnik Ines#, Gi-Cheon Kim#, Juli Choi, Hae Won Park, Diane Mathis, Christophe Benoist, Je Kyung Seong*, Gloria B. Choi*, Jun R. Huh*, Ho-Keun Kwon*. Under review
4. Beyond gut feeling: Decoding the Gut-Immune-Brain axis in health and diseases. John Chulhoon Park*, Leechung Chang*, Sin-Hyeog Im#, Ho-Keun Kwon#. Cell. Mol. Immunol., 2025 Aug 14. doi: 10.1038/s41423-025-01333-3
5. Targeting glial PD-1/PD-L1 restores microglial homeostasis and reduces neuronal hyperactivity in an Alzheimer’s disease mode. Taeyoung Park, Leechung Chang, Seung Won Chung, Seowoo Lee, Sungjun Bae, Carlo Condello, Yong Ho Kim, Jaecheol Lee, Han-Joo Kim, Ho-Keun Kwon* and Minah Suh*. Under review in Science Advances
6. Distinct T Cell Dysregulation Reflects Disease Severity and Progression in Infantile Epileptic Spasms Syndrome and Lennox-Gastaut Syndrome. Leechung Chang, Yeo-Jin Jeong, Haeun Chang, Hyeon Deok Sang, Ki-Nam Kwon, Su-Bin Lee, Si-Yoon Kim, You Min Kang, Sungji Ha, Se Hee Kim*, Keun-Ah Cheon*, and Ho-Keun Kwon*, Immune Netw. 2025 Aug;25(4):e28
7. SARS-CoV-2-driven changes in gut microbiota landscape reveal the immune-regulatory potential of Akkermansia muciniphila. Gi-Cheon Kim#, Jun-Soo Do#, Sung-Hee Kim#, Jong-Hwi Yoon, Jiseon Kim, Donghun Jeon, Emmanuel Hitayezu, Intan Rizki Mauliasari, Naeok Koo, Jeong Jin Kim, Jun-Young Seo, Su-bin Lee, Ki Taek Nam*, Kwang Hyun Cha*, Ho-Keun Kwon*, Je Kyung Seong*. Under review in Gut Microbes
8. KB-0118, a novel BET Bromodomain inhibitor, suppresses Th17-mediated inflammation in inflammatory bowel disease. Yeo-Jin Jeong, Yeon-Su Ok, Gi-Nam Kwon M,in-Young Kim, Jin Hong Chun, Sukmo Kang, Haemi Yang, Minhee Son, In-hyun Lee, Gi-Cheon Kim* ,Ho-Keun Kwon*. Biomedicine & Pharmacotherapy, Vol 185, April 2025, 117933
9. Mitochondria activity and CXCR4 collaboratively promote the differentiation of CD11c+ B cells induced by TLR9 in Lupus. Sung Hoon Jang, Joo Sung Shim, Jieun Kim, Eun Gyeol Shin, Jong Hwi Yoon, Lucy Eunju Lee, Ho-Keun Kwon*, Jason Jungsik Song*, Immune Netw. 2024 Aug;24(4):e25
10. Tacrolimus-loaded chitosan-based nanoparticles as an efficient topical therapeutic for the effective treatment of atopic dermatitis symptoms. Jin Sil Lee, Eunjeong Oh, Hyeryeon Oh, Sunghyun Kim, Subin Ok, Junseo Sa, Jeung-Hoon Lee, Yong Chul Shin, Yong-Soo Bae, Cheol Yong Choi, Sangho Lee, Ho-Keun Kwon*, Siyoung Yang*, Won Il Choi*, International Journal of Biological Macromolecules. July 2024, 133005
11. A longitudinal molecular and cellular lung atlas of lethal SARS-CoV-2 infection in K18-hACE2 transgenic mice. Seunghoon Choi, Jusung Lee, Suhyeon Kim, Youn Woo Lee, Gi-Cheon Kim, Seung-Min Hong, Se-Hee An, Hyuna Noh, Kyung Eun Kim, Dain On, Sang Gyu Lee, Hui Jeong Jang, Sung-Hee Kim, Jiseon Kim, Jung Seon Seo, Jeong Jin Kim, In Ho Park, Jooyeon Oh, Da-Jung Kim, Jong-Hwi Yoon, Sang-Hyuk Seok, Yu Jin Lee, Seo Yeon Kim, Young Been Kim, Ji-Yeon Hwang, Hyo-Jung Lee, Hong Bin Kim, Jun Won Park, Jun-Won Yun, Jeon-Soo Shin, Jun-Young Seo, Ki Taek Nam, Kang-Seuk Choi#, Ho-Keun Kwon#, Ho-Young Lee#, Jong Kyoung Kim#, Je Kyung Seong#, eBioMedicine, 2024 Jan:99:104932
12. Exploring probiotic effector molecules and their mode of action in gut–immune interactions. Choong-Gu Lee, Kwang Hyun Cha, Gi-Cheon Kim, Sin-Hyeog Im*, Ho-Keun Kwon*, FEMS Microbiol Rev. 2023 Jul 5;47(4):fuad046.
13. A Moonlighting Protein Secreted by a Nasal Microbiome Fortifies the Innate Host Defense Against Bacterial and Viral Infections. Gwanghee Kim, Yoojin Lee, Jin Sun You, Wontae Hwang, Jeewon Hwang, Hwa Young Kim, Jieun Kim, Ara Jo, In ho Park, Mohammed Ali, Jongsun Kim, Jeon-Soo Shin, Ho-Keun Kwon*, Hyun Jik Kim*, Sang Sun Yoon*, Immune Netw. 2023 Aug;23(4):e31
14. Gut Microbial Metabolites on Host Immune Responses in Health and Disease. Jong-Hwi Yoon*, Jun-Soo Do*, Priyanka Velankanni*, Choong-Gu Lee#, and Ho-Keun Kwon#, Immune Netw. 2023 Feb;23(1):e6.
15. WNK3 inhibition elicits anti-tumor immunity by suppressing PD-L1 expression on tumor cells and activating T cell function. Hyun Ju Yoon1*, Gi-Cheon Kim*, Sejin Oh, Yunji Lee, Min Seo Kim, Yong Keun Kim, Gino Kwon, Ho-Keun Kwon# &, Hyun Seok Kim#. WNK3 inhibition elicits anti-tumor immunity by suppressing PD-L1 expression on tumor cells and activating T cell function. Experimental & Molecular Medicine. 2022 Nov;54(11):1913-1926
16. Maternal inflammation and its ramifications on fetal neurodevelopment. Ho-Keun Kwon*, Gloria B Choi, Jun R Huh*. Trends in Immunology. 2022, Mar;43(3):230-244. doi: 10.1016/j.it.2022.01.007.
17. TREGking From Gut to Brain: The Control of Regulatory T Cells Along the Gut-Brain Axis. Juli Choi, Bo-Ram Kim, Begum Akuzum, Leechung Chang, June-Yong Lee#, Ho-Keun Kwon#. Front Immunol. 2022; 13: 916066.
18. New insights into the microbiota of wild mice. Ho-Keun Kwon, Je Kyung Seong. Mammalian Genome, 2021, 32, p311–318. doi: 10.1007/s00335-021-09887-z.
19. Probiotics-derived metabolite ameliorates skin allergy by promoting differentiation of FOXP3 + regulatory T cells. Hye-Ji Kang*, Gi-Cheon Kim*, Choong-Gu Lee*, Sunhee Park, Garima Sharma, Ravi Verma, Sin-Hyeog Im#, Ho-Keun Kwon#. J Allergy Clin Immunol. 2021, Apr Apr;147(4):1517-1521
20. ETS1 suppresses tumorigenesis of human breast cancer via trans-activation of canonical tumor suppressor genes. Gi-Cheon Kim, Choong-Gu Lee, Ravi Verma, Dipayan Rudra, Taemook Kim, Keunsoo Kang, Jong Hee Nam, Young Kim, Sin-Hyeog Im, Ho-Keun Kwon,FRONT ONCOL, 2020, 10(642).
21. Ets1 suppresses atopic dermatitis by suppressing pathogenic T cell responses. Choong-Gu Lee*, Ho-Keun Kwon*, Hyeji Kang*, Young Kim, Jong Hee Nam, Young Ho Won, Sunhee Park, Taemook Kim, Keunsoo Kang, Dipayan Rudra, Chang-Duk Jun, Zee Yong Park, Sin-Hyeog Im. JCI insight. 2019;4(5):e124202
