1. Interaction among gut microbiome, immune, and neuronal system (‘Immune-Gut-Brain’ axis)

Microbiome, gut residing bacteria is considered as “Hidden Organ” that plays complex roles in many biological activities such as metabolism and immune modulation in host. Moreover, recent studies support bidirectional communication among microbiome, immune, and neuronal system, known as ‘Immune-Gut-Brain axis” in which not just simple compartment but inter-communication among three different compartments have central roles to generate mutual impacts on these tangled systems. 

Previous and on-going studies in mouse model of autoimmune diseases or Autism mice address where and how the gut microbiome impacts on these disease models. More specifically, we have begun broader explorations of the interaction between host genetics, microbiome composition and activity, and how different microbe and their metabolites influence on immune or neuronal activities and, eventually, their contribution in immunological/neuro-inflammatory disorders.